| FMR LLC | 24,631,956 | $2.0bn | 0.1% |
| Capital World Investors | 21,669,226 | $1.7bn | 0.2% |
| BlackRock, Inc. | 10,704,660 | $848.8m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 7,859,529 | $623.2m | 0.0% |
| WELLINGTON MANAGEMENT GROUP LLP | 7,651,415 | $606.7m | 0.1% |
| VANGUARD CAPITAL MANAGEMENT LLC | 7,211,497 | $571.8m | 0.0% |
| TWO SIGMA INVESTMENTS, LP | 6,252,342 | $495.7m | 0.4% |
| ROYAL BANK OF CANADA | 6,182,479 | $490.2m | 0.1% |
| STATE STREET CORP | 4,334,848 | $343.7m | 0.0% |
| T. Rowe Price Investment Management, Inc. | 3,959,372 | $313.9m | 0.2% |
| GEODE CAPITAL MANAGEMENT, LLC | 3,584,024 | $294.8m | 0.0% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,184,500 | $252.5m | 0.0% |
| JPMORGAN CHASE & CO | 2,671,717 | $216.2m | 0.0% |
| Artisan Partners Limited Partnership | 2,640,024 | $209.3m | 0.3% |
| Tweedy, Browne Co LLC | 2,280,311 | $180.8m | 13.7% |
| Deep Track Capital, LP | 2,200,000 | $174.4m | 2.5% |
| GOLDMAN SACHS GROUP INC | 2,109,945 | $167.3m | 0.0% |
| BAKER BROS. ADVISORS LP | 2,047,727 | $162.4m | 0.8% |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,979,669 | $157.0m | 1.6% |
| AMERICAN CENTURY COMPANIES INC | 1,947,076 | $154.4m | 0.1% |
| FRANKLIN RESOURCES INC | 1,623,377 | $128.7m | 0.0% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,605,054 | $127.3m | 0.0% |
| BARCLAYS PLC | 1,603,136 | $127.1m | 0.0% |
| Pictet Asset Management Holding SA | 1,596,998 | $127.0m | 0.1% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,454,672 | $115.3m | 0.0% |