| Jupiter Topco LLC | 34,173,104 | $30.0m | 0.0% |
| BVF INC/IL | 28,165,000 | $24.6m | 0.6% |
| MAVERICK CAPITAL LTD | 18,970,913 | $16.6m | 0.1% |
| PERCEPTIVE ADVISORS LLC | 18,490,636 | $16.1m | 0.2% |
| BlackRock, Inc. | 16,134,885 | $14.1m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 10,496,507 | $9.2m | 0.0% |
| M28 Capital Management LP | 9,248,250 | $8.1m | 17.1% |
| Saturn V Capital Management LP | 8,392,288 | $7.3m | 1.0% |
| Soleus Capital Management, L.P. | 7,708,727 | $6.7m | 0.2% |
| Point72 Asset Management, L.P. | 7,542,061 | $6.6m | 0.0% |
| MORGAN STANLEY | 5,730,948 | $5.0m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 5,418,774 | $4.7m | 0.0% |
| Siren, L.L.C. | 5,000,000 | $4.4m | 0.1% |
| Driehaus Capital Management LLC | 4,806,543 | $4.2m | 0.0% |
| ADAR1 Capital Management, LLC | 3,807,427 | $3.3m | 0.2% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 3,661,480 | $3.2m | 0.0% |
| CITADEL ADVISORS LLC | 3,580,941 | $3.1m | 0.0% |
| STATE STREET CORP | 3,457,428 | $3.0m | 0.0% |
| Qube Research & Technologies Ltd | 3,320,238 | $2.9m | 0.0% |
| Ikarian Capital, LLC | 2,656,570 | $2.3m | 0.2% |
| Redmile Group, LLC | 2,597,759 | $2.3m | 0.2% |
| 683 Capital Management, LLC | 2,482,543 | $2.2m | 0.1% |
| TWO SIGMA INVESTMENTS, LP | 2,333,474 | $2.0m | 0.0% |
| Eversept Partners, LP | 2,237,015 | $2.0m | 0.1% |
| Ensign Peak Advisors, Inc | 1,721,276 | $1.5m | 0.0% |