| BROWN ADVISORY INC | 1,678,983 | $32.1m | 0.0% |
| BlackRock, Inc. | 1,272,714 | $24.3m | 0.0% |
| BRAIDWELL LP | 1,100,370 | $21.1m | 0.8% |
| Granahan Investment Management, LLC | 1,085,964 | $20.8m | 0.7% |
| MILLENNIUM MANAGEMENT LLC | 816,830 | $15.6m | 0.0% |
| WELLINGTON MANAGEMENT GROUP LLP | 794,309 | $15.2m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 755,624 | $14.5m | 0.0% |
| Soleus Capital Management, L.P. | 732,144 | $14.0m | 0.5% |
| MORGAN STANLEY | 693,387 | $13.3m | 0.0% |
| WASATCH ADVISORS LP | 515,677 | $9.9m | 0.1% |
| Nantahala Capital Management, LLC | 484,684 | $9.3m | 0.2% |
| DIMENSIONAL FUND ADVISORS LP | 480,848 | $9.2m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 452,354 | $8.7m | 0.0% |
| STATE STREET CORP | 391,630 | $7.5m | 0.0% |
| CITADEL ADVISORS LLC | 334,651 | $6.4m | 0.0% |
| Roubaix Capital, LLC | 306,564 | $5.9m | 2.1% |
| GOLDMAN SACHS GROUP INC | 304,712 | $5.8m | 0.0% |
| AIGH Capital Management LLC | 269,765 | $5.2m | 0.3% |
| AWM Investment Company, Inc. | 237,169 | $4.5m | 0.4% |
| Nuveen, LLC | 222,869 | $4.3m | 0.0% |
| HARBOR CAPITAL ADVISORS, INC. | 199,682 | $3.8m | 0.3% |
| Squarepoint Ops LLC | 195,468 | $3.7m | 0.0% |
| DAFNA Capital Management LLC | 189,130 | $3.6m | 0.7% |
| KENNEDY CAPITAL MANAGEMENT LLC | 182,871 | $3.5m | 0.1% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 171,268 | $3.3m | 0.0% |