| BAKER BROS. ADVISORS LP | 19,919,186 | $776.1m | 3.9% |
| BlackRock, Inc. | 4,135,355 | $161.1m | 0.0% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,248,611 | $126.6m | 0.0% |
| STATE STREET CORP | 2,419,417 | $94.3m | 0.0% |
| GOLDMAN SACHS GROUP INC | 2,316,014 | $90.2m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 1,804,632 | $70.3m | 0.0% |
| BRAIDWELL LP | 1,787,318 | $69.6m | 2.6% |
| Jupiter Topco LLC | 1,526,006 | $59.5m | 0.0% |
| RTW INVESTMENTS, LP | 1,487,934 | $58.0m | 0.5% |
| Boxer Capital Management, LLC | 1,477,600 | $57.6m | 4.3% |
| T. Rowe Price Investment Management, Inc. | 1,477,033 | $57.5m | 0.0% |
| TCG Crossover Management, LLC | 1,445,538 | $56.3m | 1.4% |
| ICONIQ Capital, LLC | 1,266,563 | $49.3m | 1.4% |
| GEODE CAPITAL MANAGEMENT, LLC | 1,062,955 | $41.4m | 0.0% |
| Ikarian Capital, LLC | 1,059,730 | $41.3m | 4.4% |
| Artisan Partners Limited Partnership | 968,037 | $37.7m | 0.1% |
| WELLINGTON MANAGEMENT GROUP LLP | 793,613 | $30.9m | 0.0% |
| Board of Trustees of The Leland Stanford Junior University | 691,767 | $27.0m | 5.1% |
| SILVERARC CAPITAL MANAGEMENT, LLC | 546,256 | $21.3m | 2.2% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 532,819 | $20.8m | 0.0% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 500,000 | $19.5m | 0.0% |
| Squadron Capital Management LLC | 500,000 | $19.5m | 6.0% |
| TWO SIGMA INVESTMENTS, LP | 473,001 | $18.4m | 0.0% |
| MORGAN STANLEY | 435,029 | $16.9m | 0.0% |
| BANK OF AMERICA CORP /DE/ | 383,709 | $14.9m | 0.0% |