| GordonMD Global Investments LP | 4,244,818 | $37.8m | 18.3% |
| GILEAD SCIENCES, INC. | 4,126,119 | $36.8m | 2.2% |
| BlackRock, Inc. | 3,134,807 | $27.9m | 0.0% |
| Bain Capital Life Sciences Investors, LLC | 2,885,000 | $25.7m | 1.5% |
| AIGH Capital Management LLC | 2,795,797 | $24.9m | 1.6% |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 2,000,000 | $17.8m | 0.2% |
| VANGUARD CAPITAL MANAGEMENT LLC | 1,897,451 | $16.9m | 0.0% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,186,023 | $10.6m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 1,049,430 | $9.4m | 0.0% |
| Insight Holdings Group, LLC | 989,054 | $8.8m | 0.7% |
| MORGAN STANLEY | 982,307 | $8.8m | 0.0% |
| STATE STREET CORP | 982,233 | $8.8m | 0.0% |
| Propel Bio Management, LLC | 883,198 | $7.9m | 4.1% |
| Woodline Partners LP | 845,325 | $7.5m | 0.0% |
| MILLENNIUM MANAGEMENT LLC | 639,780 | $5.7m | 0.0% |
| MBB PUBLIC MARKETS I LLC | 614,477 | $5.5m | 0.6% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 500,000 | $4.5m | 0.0% |
| D. E. Shaw & Co., Inc. | 469,346 | $4.2m | 0.0% |
| WELLS FARGO & COMPANY/MN | 373,009 | $3.3m | 0.0% |
| UBS Group AG | 365,574 | $3.3m | 0.0% |
| GOLDMAN SACHS GROUP INC | 335,230 | $3.0m | 0.0% |
| RENAISSANCE TECHNOLOGIES LLC | 333,899 | $3.0m | 0.0% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 319,666 | $2.8m | 0.0% |
| NORTHERN TRUST CORP | 315,354 | $2.8m | 0.0% |
| BNP PARIBAS FINANCIAL MARKETS | 310,632 | $2.8m | 0.0% |