| RA CAPITAL MANAGEMENT, L.P. | 4,178,823 | $23.7m | 0.2% |
| Alpha Wave Global, LP | 3,612,211 | $20.5m | 0.3% |
| FMR LLC | 3,558,905 | $20.2m | 0.0% |
| Versant Venture Management, LLC | 2,656,888 | $15.1m | 9.3% |
| BlackRock, Inc. | 2,292,121 | $13.0m | 0.0% |
| Squarepoint Ops LLC | 1,747,096 | $9.9m | 0.0% |
| Aberdeen Group plc | 1,547,883 | $8.8m | 0.0% |
| MILLENNIUM MANAGEMENT LLC | 1,508,478 | $8.6m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 1,097,755 | $6.2m | 0.0% |
| 72 Investment Holdings, LLC | 1,017,751 | $5.8m | 11.6% |
| Blue Owl Capital Holdings LP | 756,722 | $4.3m | 0.6% |
| C WorldWide Group Holding A/S | 700,000 | $4.0m | 0.1% |
| GEODE CAPITAL MANAGEMENT, LLC | 564,662 | $3.2m | 0.0% |
| Trexquant Investment LP | 497,526 | $2.8m | 0.0% |
| MARSHALL WACE, LLP | 493,099 | $2.8m | 0.0% |
| Qube Research & Technologies Ltd | 482,195 | $2.7m | 0.0% |
| MORGAN STANLEY | 472,995 | $2.7m | 0.0% |
| PRIMECAP MANAGEMENT CO/CA/ | 472,200 | $2.7m | 0.0% |
| TANG CAPITAL MANAGEMENT LLC | 451,114 | $2.6m | 0.1% |
| Alyeska Investment Group, L.P. | 438,882 | $2.5m | 0.0% |
| STATE STREET CORP | 406,674 | $2.3m | 0.0% |
| CITADEL ADVISORS LLC | 363,229 | $2.1m | 0.0% |
| TWO SIGMA INVESTMENTS, LP | 285,584 | $1.6m | 0.0% |
| Rock Springs Capital Management LP | 257,460 | $1.5m | 0.1% |
| BANK OF AMERICA CORP /DE/ | 255,410 | $1.5m | 0.0% |