| BlackRock, Inc. | 10,788,586 | $860.2m | 0.0% |
| FARALLON CAPITAL MANAGEMENT, L.L.C. | 8,365,038 | $666.9m | 3.1% |
| Caligan Partners LP | 8,118,892 | $647.3m | 30.5% |
| FINDELL CAPITAL MANAGEMENT LLC | 3,502,112 | $279.2m | 39.3% |
| VANGUARD CAPITAL MANAGEMENT LLC | 3,139,183 | $250.3m | 0.0% |
| STATE STREET CORP | 3,030,395 | $241.6m | 0.0% |
| Opaleye Management Inc. | 2,447,500 | $195.1m | 17.7% |
| GEODE CAPITAL MANAGEMENT, LLC | 2,121,290 | $169.2m | 0.0% |
| BANK OF AMERICA CORP /DE/ | 1,991,566 | $158.8m | 0.0% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,940,364 | $154.7m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 1,532,151 | $122.2m | 0.0% |
| Caprock Group, LLC | 1,409,759 | $112.4m | 2.2% |
| MPM BIOIMPACT LLC | 1,386,174 | $110.5m | 6.7% |
| D. E. Shaw & Co., Inc. | 1,267,706 | $101.1m | 0.0% |
| FULLER & THALER ASSET MANAGEMENT, INC. | 1,209,604 | $96.4m | 0.3% |
| GOLDMAN SACHS GROUP INC | 958,892 | $76.5m | 0.0% |
| FEDERATED HERMES, INC. | 816,187 | $65.1m | 0.1% |
| NORTHERN TRUST CORP | 709,063 | $56.5m | 0.0% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 674,033 | $53.7m | 0.0% |
| MORGAN STANLEY | 658,441 | $52.5m | 0.0% |
| BOOTHBAY FUND MANAGEMENT, LLC | 622,716 | $49.6m | 0.7% |
| UBS Group AG | 606,558 | $48.4m | 0.0% |
| FMR LLC | 595,629 | $47.5m | 0.0% |
| AMERICAN CENTURY COMPANIES INC | 542,131 | $43.2m | 0.0% |
| VANGUARD FIDUCIARY TRUST CO | 503,774 | $40.2m | 0.0% |