| DEERFIELD MANAGEMENT COMPANY, L.P. | 35,606,974 | $108.6m | 1.1% |
| Blue Owl Capital Holdings LP | 9,163,157 | $27.9m | 4.2% |
| BlackRock, Inc. | 5,678,035 | $17.3m | 0.0% |
| Defilade Capital Management, L.P. | 3,670,135 | $11.2m | 1.5% |
| Driehaus Capital Management LLC | 3,163,423 | $9.6m | 0.1% |
| VANGUARD CAPITAL MANAGEMENT LLC | 2,974,901 | $9.1m | 0.0% |
| RTW INVESTMENTS, LP | 2,565,999 | $7.8m | 0.1% |
| AQR CAPITAL MANAGEMENT LLC | 2,371,414 | $7.2m | 0.0% |
| MARSHALL WACE, LLP | 2,012,458 | $6.1m | 0.0% |
| DAFNA Capital Management LLC | 2,008,164 | $6.1m | 1.2% |
| GOLDMAN SACHS GROUP INC | 1,752,910 | $5.3m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 1,679,003 | $5.1m | 0.0% |
| Qube Research & Technologies Ltd | 1,641,042 | $5.0m | 0.0% |
| CITADEL ADVISORS LLC | 1,456,825 | $4.4m | 0.0% |
| STATE STREET CORP | 1,411,804 | $4.3m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 1,403,172 | $4.3m | 0.0% |
| Woodline Partners LP | 1,400,850 | $4.3m | 0.0% |
| MILLENNIUM MANAGEMENT LLC | 1,333,037 | $4.1m | 0.0% |
| DIMENSIONAL FUND ADVISORS LP | 961,083 | $2.9m | 0.0% |
| FMR LLC | 937,368 | $2.9m | 0.0% |
| SPHERA FUNDS MANAGEMENT LTD. | 926,004 | $2.8m | 0.4% |
| Nuveen, LLC | 895,304 | $2.7m | 0.0% |
| Alyeska Investment Group, L.P. | 617,211 | $1.9m | 0.0% |
| NORTHERN TRUST CORP | 550,266 | $1.7m | 0.0% |
| VANGUARD FIDUCIARY TRUST CO | 448,168 | $1.4m | 0.0% |