| PRIMECAP MANAGEMENT CO/CA/ | 4,612,331 | $6.0m | 0.0% |
| MORGAN STANLEY | 2,922,921 | $3.8m | 0.0% |
| Soleus Capital Management, L.P. | 2,788,323 | $3.6m | 0.1% |
| VANGUARD CAPITAL MANAGEMENT LLC | 1,630,219 | $2.1m | 0.0% |
| ExodusPoint Capital Management, LP | 1,223,555 | $1.6m | 0.0% |
| Almitas Capital LLC | 1,064,202 | $1.4m | 0.3% |
| BlackRock, Inc. | 882,490 | $1.1m | 0.0% |
| Stonepine Capital Management, LLC | 815,436 | $1.1m | 0.3% |
| JANE STREET GROUP, LLC | 758,231 | $985,700 | 0.0% |
| BRAIDWELL LP | 752,541 | $978,303 | 0.0% |
| AQR CAPITAL MANAGEMENT LLC | 744,963 | $968,453 | 0.0% |
| Parkman Healthcare Partners LLC | 646,564 | $840,533 | 0.1% |
| GEODE CAPITAL MANAGEMENT, LLC | 452,684 | $588,714 | 0.0% |
| RENAISSANCE TECHNOLOGIES LLC | 425,110 | $552,643 | 0.0% |
| ADAR1 Capital Management, LLC | 404,497 | $525,846 | 0.0% |
| DEUTSCHE BANK AG\ | 402,316 | $523,011 | 0.0% |
| D. E. Shaw & Co., Inc. | 327,528 | $425,787 | 0.0% |
| Jefferies Financial Group Inc. | 285,110 | $370,643 | 0.0% |
| CFM WEALTH PARTNERS LLC | 264,039 | $343,251 | 0.0% |
| VANGUARD FIDUCIARY TRUST CO | 250,511 | $325,664 | 0.0% |
| MARSHALL WACE, LLP | 230,738 | $299,959 | 0.0% |
| ACADIAN ASSET MANAGEMENT LLC | 223,141 | $287,000 | 0.0% |
| MILLENNIUM MANAGEMENT LLC | 209,556 | $272,423 | 0.0% |
| UBS Group AG | 204,053 | $265,269 | 0.0% |
| Birchview Capital, LP | 200,543 | $260,706 | 0.1% |