| BlackRock, Inc. | 32,133,223 | $136.9m | 0.0% |
| Rubric Capital Management LP | 18,000,000 | $76.7m | 0.7% |
| STATE STREET CORP | 16,174,043 | $68.9m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 13,169,392 | $56.1m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 7,947,203 | $33.9m | 0.0% |
| WELLINGTON MANAGEMENT GROUP LLP | 7,844,807 | $33.4m | 0.0% |
| Frazier Life Sciences Management, L.P. | 6,600,000 | $28.1m | 0.6% |
| Deep Track Capital, LP | 6,000,000 | $25.6m | 0.4% |
| 180 WEALTH ADVISORS, LLC | 4,959,351 | $21.1m | 2.1% |
| FMR LLC | 4,101,046 | $17.5m | 0.0% |
| TSP Capital Management Group, LLC | 3,972,675 | $16.9m | 4.0% |
| AQR CAPITAL MANAGEMENT LLC | 3,808,824 | $16.2m | 0.0% |
| MORGAN STANLEY | 3,474,870 | $14.8m | 0.0% |
| BRAIDWELL LP | 3,458,429 | $14.7m | 0.5% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 3,002,169 | $12.8m | 0.0% |
| NORTHERN TRUST CORP | 2,887,290 | $12.3m | 0.0% |
| UBS Group AG | 2,886,231 | $12.3m | 0.0% |
| TWO SIGMA INVESTMENTS, LP | 2,693,712 | $11.5m | 0.0% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 2,598,727 | $11.1m | 0.0% |
| BANK OF AMERICA CORP /DE/ | 2,364,872 | $10.1m | 0.0% |
| VANGUARD FIDUCIARY TRUST CO | 2,196,779 | $9.4m | 0.0% |
| GOLDMAN SACHS GROUP INC | 2,154,499 | $9.2m | 0.0% |
| WELLS FARGO & COMPANY/MN | 1,476,413 | $6.3m | 0.0% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,180,803 | $5.0m | 0.0% |
| DIMENSIONAL FUND ADVISORS LP | 1,094,192 | $4.7m | 0.0% |