| BlackRock, Inc. | 60,029,175 | $5.8bn | 0.1% |
| VANGUARD CAPITAL MANAGEMENT LLC | 45,682,732 | $4.4bn | 0.1% |
| STATE STREET CORP | 36,082,601 | $3.5bn | 0.1% |
| Invesco Ltd. | 32,685,479 | $3.1bn | 0.2% |
| JPMORGAN CHASE & CO | 29,719,793 | $2.9bn | 0.2% |
| LOOMIS SAYLES & CO L P | 24,849,175 | $2.4bn | 3.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 20,321,184 | $2.0bn | 0.1% |
| ALLIANCEBERNSTEIN L.P. | 27,060,016 | $2.0bn | 0.7% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 15,025,043 | $1.4bn | 0.1% |
| BANK OF AMERICA CORP /DE/ | 12,436,117 | $1.2bn | 0.1% |
| MORGAN STANLEY | 12,308,366 | $1.2bn | 0.1% |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 9,905,932 | $952.2m | 0.7% |
| FMR LLC | 9,689,025 | $931.3m | 0.0% |
| BROADWOOD CAPITAL INC | 8,107,796 | $779.3m | 40.7% |
| NORGES BANK | 7,674,799 | $737.7m | 0.1% |
| WELLINGTON MANAGEMENT GROUP LLP | 7,465,974 | $717.6m | 0.1% |
| NORTHERN TRUST CORP | 7,407,177 | $712.0m | 0.1% |
| Ninety One UK Ltd | 6,930,282 | $666.1m | 1.5% |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 6,725,020 | $653.7m | 0.2% |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 6,710,230 | $645.0m | 0.3% |
| Jupiter Topco LLC | 6,170,193 | $593.1m | 0.2% |
| Capital Research Global Investors | 5,981,701 | $575.0m | 0.1% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 5,709,532 | $548.8m | 0.1% |
| GOLDMAN SACHS GROUP INC | 5,644,561 | $542.6m | 0.0% |
| Clearbridge Investments, LLC | 5,568,869 | $535.3m | 0.4% |