| BlackRock, Inc. | 13,711,607 | $2.3bn | 0.0% |
| JPMORGAN CHASE & CO | 6,398,674 | $1.1bn | 0.1% |
| Dodge & Cox | 5,584,707 | $941.2m | 0.5% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 4,974,083 | $838.3m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 4,545,339 | $766.0m | 0.0% |
| STATE STREET CORP | 4,385,598 | $739.1m | 0.0% |
| AQR CAPITAL MANAGEMENT LLC | 3,818,037 | $643.5m | 0.2% |
| RENAISSANCE TECHNOLOGIES LLC | 2,335,897 | $393.7m | 0.5% |
| GEODE CAPITAL MANAGEMENT, LLC | 2,138,777 | $359.6m | 0.0% |
| TWO SIGMA INVESTMENTS, LP | 2,076,260 | $349.9m | 0.3% |
| Vestal Point Capital, LP | 1,880,000 | $316.8m | 7.4% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 1,494,259 | $251.9m | 0.3% |
| MORGAN STANLEY | 1,318,607 | $222.2m | 0.0% |
| RTW INVESTMENTS, LP | 1,267,925 | $213.7m | 1.8% |
| NORTHERN TRUST CORP | 1,259,717 | $212.3m | 0.0% |
| Invesco Ltd. | 1,077,317 | $181.6m | 0.0% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 974,279 | $164.2m | 0.0% |
| NORGES BANK | 973,880 | $164.1m | 0.0% |
| FIRST TRUST ADVISORS LP | 923,125 | $155.6m | 0.1% |
| DIMENSIONAL FUND ADVISORS LP | 732,877 | $123.5m | 0.0% |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 726,112 | $122.4m | 0.4% |
| Bank of New York Mellon Corp | 699,125 | $117.8m | 0.0% |
| Swedbank AB | 651,082 | $109.7m | 0.1% |
| VANGUARD FIDUCIARY TRUST CO | 647,763 | $109.2m | 0.0% |
| IEQ CAPITAL, LLC | 640,304 | $107.9m | 0.5% |