| FMR LLC | 52,230,295 | $296.7m | 0.0% |
| BlackRock, Inc. | 27,630,837 | $156.9m | 0.0% |
| Decheng Capital LLC | 25,954,439 | $147.4m | 20.1% |
| VANGUARD CAPITAL MANAGEMENT LLC | 11,919,514 | $67.7m | 0.0% |
| Omega Fund Management, LLC | 8,081,089 | $45.9m | 24.7% |
| Laurion Capital Management LP | 7,820,013 | $44.4m | 1.1% |
| STATE STREET CORP | 7,370,794 | $41.9m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 6,244,805 | $35.5m | 0.0% |
| Duquesne Family Office LLC | 4,539,800 | $25.8m | 0.5% |
| AMERICAN CENTURY COMPANIES INC | 4,499,643 | $25.6m | 0.0% |
| BANK OF AMERICA CORP /DE/ | 3,529,748 | $20.0m | 0.0% |
| TANG CAPITAL MANAGEMENT LLC | 3,299,557 | $18.7m | 0.9% |
| Redmile Group, LLC | 3,031,009 | $17.2m | 1.2% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 2,688,666 | $15.3m | 0.0% |
| AQR CAPITAL MANAGEMENT LLC | 2,356,429 | $13.4m | 0.0% |
| NORTHERN TRUST CORP | 2,321,873 | $13.2m | 0.0% |
| ALGERT GLOBAL LLC | 2,277,358 | $12.9m | 0.2% |
| HRT FINANCIAL LP | 2,207,779 | $12.5m | 0.0% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 2,058,870 | $11.7m | 0.0% |
| DIMENSIONAL FUND ADVISORS LP | 2,047,876 | $11.6m | 0.0% |
| ARMISTICE CAPITAL, LLC | 2,000,000 | $11.4m | 0.1% |
| CITADEL ADVISORS LLC | 1,988,330 | $11.3m | 0.0% |
| GOLDMAN SACHS GROUP INC | 1,904,686 | $10.8m | 0.0% |
| VANGUARD FIDUCIARY TRUST CO | 1,776,554 | $10.1m | 0.0% |
| Connor, Clark & Lunn Investment Management Ltd. | 1,756,820 | $10.0m | 0.0% |