| FMR LLC | 12,143,062 | $151.9m | 0.0% |
| Paradigm Biocapital Advisors LP | 8,670,576 | $108.5m | 2.0% |
| Jupiter Topco LLC | 7,094,413 | $88.8m | 0.0% |
| Bain Capital Life Sciences Investors, LLC | 7,085,249 | $88.6m | 5.3% |
| BlackRock, Inc. | 6,714,691 | $84.0m | 0.0% |
| BVF INC/IL | 5,295,893 | $66.3m | 1.7% |
| Siren, L.L.C. | 4,856,949 | $60.8m | 1.2% |
| STATE STREET CORP | 4,316,058 | $54.0m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 3,341,217 | $41.8m | 0.0% |
| Logos Global Management LP | 3,208,875 | $40.1m | 1.7% |
| FRANKLIN RESOURCES INC | 2,349,586 | $29.4m | 0.0% |
| Cormorant Asset Management, LP | 2,150,000 | $26.9m | 1.4% |
| MORGAN STANLEY | 1,832,269 | $22.9m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 1,819,029 | $22.8m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 1,663,218 | $20.8m | 0.0% |
| GOLDMAN SACHS GROUP INC | 1,567,979 | $19.6m | 0.0% |
| Deep Track Capital, LP | 1,500,000 | $18.8m | 0.3% |
| DIMENSIONAL FUND ADVISORS LP | 1,416,533 | $17.7m | 0.0% |
| LIGHTSPEED MANAGEMENT COMPANY, L.L.C. | 1,355,299 | $17.0m | 0.7% |
| KINGDON CAPITAL MANAGEMENT, L.L.C. | 1,200,000 | $15.0m | 1.5% |
| TWO SIGMA INVESTMENTS, LP | 1,131,434 | $14.2m | 0.0% |
| Point72 Asset Management, L.P. | 1,070,949 | $13.4m | 0.0% |
| Duquesne Family Office LLC | 986,827 | $12.3m | 0.2% |
| Defilade Capital Management, L.P. | 924,758 | $11.6m | 1.5% |
| AMERIPRISE FINANCIAL INC | 840,646 | $10.5m | 0.0% |