| Nextech Invest Ltd. | 7,162,637 | $77.6m | 3.7% |
| BlackRock, Inc. | 6,823,973 | $73.9m | 0.0% |
| EcoR1 Capital, LLC | 6,728,116 | $72.9m | 3.5% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 6,617,554 | $71.7m | 0.0% |
| VIKING GLOBAL INVESTORS LP | 5,126,762 | $55.5m | 0.2% |
| STATE STREET CORP | 4,894,000 | $53.0m | 0.0% |
| SR One Capital Management, LP | 4,615,384 | $50.0m | 4.8% |
| Venrock Adviser, LLC | 4,319,765 | $46.8m | 1.4% |
| NEA Management Company, LLC | 4,118,621 | $44.6m | 2.8% |
| VANGUARD CAPITAL MANAGEMENT LLC | 3,951,169 | $42.8m | 0.0% |
| AIHC Capital Management Ltd | 3,828,460 | $41.5m | 39.8% |
| ALKEON CAPITAL MANAGEMENT LLC | 3,739,096 | $40.5m | 0.1% |
| Column Group LLC | 3,540,777 | $38.3m | 43.5% |
| Siren, L.L.C. | 2,998,192 | $32.5m | 0.7% |
| FMR LLC | 2,635,475 | $28.5m | 0.0% |
| CITADEL ADVISORS LLC | 2,595,299 | $28.1m | 0.0% |
| GOLDMAN SACHS GROUP INC | 2,451,796 | $26.6m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 2,090,089 | $22.6m | 0.0% |
| First Turn Management, LLC | 2,017,284 | $21.8m | 2.3% |
| ORBIMED ADVISORS LLC | 2,015,000 | $21.8m | 0.4% |
| Integral Health Asset Management, LLC | 1,900,000 | $20.6m | 0.8% |
| MPM BIOIMPACT LLC | 1,882,162 | $20.4m | 1.2% |
| Vivo Capital, LLC | 1,848,786 | $20.0m | 1.8% |
| DIMENSIONAL FUND ADVISORS LP | 1,801,399 | $19.5m | 0.0% |
| FRANKLIN RESOURCES INC | 1,797,377 | $19.5m | 0.0% |