| FMR LLC | 9,057,645 | $862.0m | 0.0% |
| BlackRock, Inc. | 4,990,181 | $474.9m | 0.0% |
| Venrock Adviser, LLC | 4,148,428 | $394.8m | 12.0% |
| Fairmount Funds Management LLC | 3,705,262 | $352.6m | 23.3% |
| Capital World Investors | 3,401,639 | $323.7m | 0.0% |
| RTW INVESTMENTS, LP | 3,139,030 | $298.7m | 2.6% |
| STATE STREET CORP | 2,673,090 | $254.4m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 2,360,971 | $224.7m | 0.0% |
| Paradigm Biocapital Advisors LP | 2,144,526 | $204.1m | 3.8% |
| Deep Track Capital, LP | 1,926,000 | $183.3m | 2.7% |
| Bellevue Group AG | 1,657,190 | $157.7m | 3.3% |
| FRANKLIN RESOURCES INC | 1,621,451 | $154.3m | 0.0% |
| Remedium Capital Partners, LLC | 1,565,661 | $149.0m | 33.0% |
| RA CAPITAL MANAGEMENT, L.P. | 1,554,597 | $148.0m | 1.3% |
| VIKING GLOBAL INVESTORS LP | 1,503,478 | $143.1m | 0.4% |
| GEODE CAPITAL MANAGEMENT, LLC | 1,429,954 | $136.1m | 0.0% |
| Jupiter Topco LLC | 1,375,844 | $131.0m | 0.1% |
| PERCEPTIVE ADVISORS LLC | 1,345,063 | $128.0m | 1.9% |
| Polar Capital Holdings Plc | 1,228,609 | $116.9m | 0.3% |
| CITADEL ADVISORS LLC | 1,119,011 | $106.5m | 0.0% |
| T. Rowe Price Investment Management, Inc. | 1,103,743 | $105.0m | 0.1% |
| BNP PARIBAS FINANCIAL MARKETS | 1,079,015 | $102.7m | 0.0% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 838,603 | $79.8m | 0.0% |
| Avidity Partners Management LP | 760,424 | $72.4m | 11.6% |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 658,301 | $62.7m | 1.1% |