| Jupiter Topco LLC | 20,741,234 | $55.9m | 0.0% |
| EVENTIDE ASSET MANAGEMENT, LLC | 11,812,241 | $31.8m | 0.4% |
| BlackRock, Inc. | 10,823,480 | $29.1m | 0.0% |
| RA CAPITAL MANAGEMENT, L.P. | 10,500,968 | $28.2m | 0.2% |
| Affinity Asset Advisors, LLC | 10,144,562 | $27.3m | 1.2% |
| STATE STREET CORP | 7,900,765 | $21.3m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 7,760,114 | $20.9m | 0.0% |
| ADAR1 Capital Management, LLC | 7,417,479 | $20.0m | 0.9% |
| Balyasny Asset Management L.P. | 6,719,076 | $18.1m | 0.0% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 6,163,781 | $16.6m | 0.0% |
| FEDERATED HERMES, INC. | 5,951,666 | $16.0m | 0.0% |
| BRAIDWELL LP | 5,919,464 | $15.9m | 0.6% |
| GEODE CAPITAL MANAGEMENT, LLC | 4,072,653 | $11.0m | 0.0% |
| SILVERARC CAPITAL MANAGEMENT, LLC | 3,101,129 | $8.3m | 0.9% |
| STEMPOINT CAPITAL LP | 2,417,283 | $6.5m | 1.1% |
| Ikarian Capital, LLC | 2,269,704 | $6.1m | 0.7% |
| Point72 Asset Management, L.P. | 1,945,727 | $5.2m | 0.0% |
| SPHERA FUNDS MANAGEMENT LTD. | 1,353,000 | $3.6m | 0.5% |
| NORTHERN TRUST CORP | 1,246,139 | $3.4m | 0.0% |
| VANGUARD FIDUCIARY TRUST CO | 1,140,753 | $3.1m | 0.0% |
| Propel Bio Management, LLC | 1,115,538 | $3.0m | 1.6% |
| Rosalind Advisors, Inc. | 1,107,994 | $3.0m | 1.1% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 1,030,943 | $2.8m | 0.0% |
| Sio Capital Management, LLC | 1,005,334 | $2.7m | 0.4% |
| Ensign Peak Advisors, Inc | 988,084 | $2.7m | 0.0% |