| Frazier Life Sciences Management, L.P. | 12,466,489 | $135.3m | 2.9% |
| Medicxi Ventures Management (Jersey) Ltd | 7,464,572 | $81.0m | 45.6% |
| BlackRock, Inc. | 4,525,129 | $49.1m | 0.0% |
| Invesco Ltd. | 4,029,731 | $43.7m | 0.0% |
| Carlyle Group Inc. | 3,496,808 | $37.9m | 0.4% |
| MILLENNIUM MANAGEMENT LLC | 3,375,834 | $36.6m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 2,656,944 | $28.8m | 0.0% |
| GW&K Investment Management, LLC | 2,166,838 | $23.5m | 0.2% |
| FRANKLIN RESOURCES INC | 1,970,828 | $21.4m | 0.0% |
| NEA Management Company, LLC | 1,960,169 | $21.3m | 1.3% |
| 683 Capital Management, LLC | 1,850,000 | $20.1m | 1.0% |
| GOLDMAN SACHS GROUP INC | 1,778,032 | $19.3m | 0.0% |
| STATE STREET CORP | 1,586,323 | $17.2m | 0.0% |
| Catalys Pacific, LLC | 1,493,854 | $16.2m | 7.1% |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 1,462,738 | $15.9m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 1,315,687 | $14.3m | 0.0% |
| WASATCH ADVISORS LP | 1,307,247 | $14.2m | 0.1% |
| Ensign Peak Advisors, Inc | 1,051,913 | $11.4m | 0.0% |
| Propel Bio Management, LLC | 1,050,358 | $11.4m | 6.0% |
| Point72 Asset Management, L.P. | 1,022,193 | $11.1m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 796,631 | $8.6m | 0.0% |
| SummitTX Capital, L.P. | 789,550 | $8.6m | 0.2% |
| HSBC HOLDINGS PLC | 709,695 | $7.7m | 0.0% |
| MARSHALL WACE, LLP | 666,090 | $7.2m | 0.0% |
| EcoR1 Capital, LLC | 625,000 | $6.8m | 0.3% |