| BlackRock, Inc. | 6,690,192 | $1.0bn | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 4,525,333 | $689.0m | 0.0% |
| STATE STREET CORP | 3,197,555 | $486.8m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 3,075,932 | $468.3m | 0.0% |
| AQR CAPITAL MANAGEMENT LLC | 2,455,135 | $373.8m | 0.1% |
| BAILLIE GIFFORD & CO | 2,042,313 | $310.9m | 0.3% |
| GEODE CAPITAL MANAGEMENT, LLC | 2,003,861 | $304.0m | 0.0% |
| TWO SIGMA INVESTMENTS, LP | 1,903,734 | $289.8m | 0.2% |
| Invesco Ltd. | 1,694,651 | $258.0m | 0.0% |
| T. Rowe Price Investment Management, Inc. | 1,512,160 | $230.2m | 0.2% |
| MORGAN STANLEY | 1,479,050 | $225.2m | 0.0% |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 1,471,069 | $224.0m | 0.1% |
| Clearbridge Investments, LLC | 1,319,381 | $200.9m | 0.2% |
| Soleus Capital Management, L.P. | 1,049,000 | $159.7m | 5.5% |
| NORGES BANK | 1,047,986 | $159.6m | 0.0% |
| JUPITER ASSET MANAGEMENT LTD | 1,026,691 | $156.3m | 0.8% |
| FMR LLC | 964,297 | $146.8m | 0.0% |
| MILLENNIUM MANAGEMENT LLC | 865,387 | $131.8m | 0.0% |
| FIL Ltd | 840,026 | $127.9m | 0.1% |
| GOLDMAN SACHS GROUP INC | 818,265 | $124.6m | 0.0% |
| CITADEL ADVISORS LLC | 796,746 | $121.3m | 0.0% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 773,361 | $117.7m | 0.0% |
| FEDERATED HERMES, INC. | 702,194 | $106.9m | 0.2% |
| Vestal Point Capital, LP | 670,000 | $102.0m | 2.4% |
| Qube Research & Technologies Ltd | 663,968 | $101.1m | 0.1% |