| Jupiter Topco LLC | 3,421,374 | $1.1bn | 0.5% |
| FMR LLC | 2,316,907 | $775.7m | 0.0% |
| BlackRock, Inc. | 2,292,585 | $767.5m | 0.0% |
| PERCEPTIVE ADVISORS LLC | 2,035,986 | $681.6m | 10.2% |
| BAKER BROS. ADVISORS LP | 1,753,198 | $587.0m | 2.9% |
| Orbis Allan Gray Ltd | 1,529,788 | $512.2m | 1.8% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 1,335,185 | $447.0m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 1,235,299 | $413.6m | 0.0% |
| STATE STREET CORP | 1,026,443 | $343.7m | 0.0% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,015,480 | $340.0m | 0.5% |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 963,351 | $322.5m | 3.4% |
| Driehaus Capital Management LLC | 959,048 | $321.1m | 1.9% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 942,999 | $315.7m | 0.0% |
| MORGAN STANLEY | 854,112 | $285.9m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 748,039 | $250.5m | 0.0% |
| Cormorant Asset Management, LP | 640,000 | $214.3m | 11.0% |
| GOLDMAN SACHS GROUP INC | 548,830 | $183.7m | 0.0% |
| BANK OF AMERICA CORP /DE/ | 546,930 | $183.1m | 0.0% |
| Invesco Ltd. | 537,548 | $180.0m | 0.0% |
| Hood River Capital Management LLC | 425,167 | $142.3m | 1.0% |
| NORGES BANK | 346,969 | $116.2m | 0.0% |
| FRANKLIN RESOURCES INC | 327,124 | $109.5m | 0.0% |
| Pictet Asset Management Holding SA | 291,689 | $98.0m | 0.1% |
| Polar Capital Holdings Plc | 279,131 | $93.5m | 0.2% |
| Vivo Capital, LLC | 271,116 | $90.8m | 8.3% |