| BlackRock, Inc. | 13,964,554 | $1.1bn | 0.0% |
| RTW INVESTMENTS, LP | 7,746,415 | $631.9m | 5.4% |
| Jupiter Topco LLC | 7,236,402 | $590.2m | 0.2% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 4,928,111 | $402.0m | 0.0% |
| STATE STREET CORP | 4,598,952 | $375.1m | 0.0% |
| WELLINGTON MANAGEMENT GROUP LLP | 4,128,273 | $336.7m | 0.1% |
| VANGUARD CAPITAL MANAGEMENT LLC | 3,739,127 | $305.0m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 2,207,376 | $180.1m | 0.0% |
| TORONTO DOMINION BANK | 2,165,846 | $176.7m | 0.2% |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 1,956,156 | $159.6m | 0.5% |
| Hood River Capital Management LLC | 1,738,613 | $141.8m | 1.0% |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 1,722,688 | $140.5m | 0.4% |
| D. E. Shaw & Co., Inc. | 1,548,919 | $126.3m | 0.1% |
| TANG CAPITAL MANAGEMENT LLC | 1,500,000 | $122.4m | 5.6% |
| BANK OF AMERICA CORP /DE/ | 1,452,277 | $118.5m | 0.0% |
| Driehaus Capital Management LLC | 1,440,107 | $117.5m | 0.7% |
| FMR LLC | 1,398,261 | $114.1m | 0.0% |
| Jefferies Financial Group Inc. | 1,357,042 | $110.7m | 0.7% |
| FULLER & THALER ASSET MANAGEMENT, INC. | 1,156,819 | $94.4m | 0.3% |
| Pictet Asset Management Holding SA | 1,147,844 | $93.6m | 0.1% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,114,516 | $90.9m | 0.0% |
| MORGAN STANLEY | 1,103,675 | $90.0m | 0.0% |
| ARMISTICE CAPITAL, LLC | 1,071,395 | $87.4m | 1.1% |
| Blue Sparrow, LLC /DE | 1,050,700 | $85.7m | 0.8% |
| FRANKLIN RESOURCES INC | 1,027,327 | $83.8m | 0.0% |