| BlackRock, Inc. | 10,307,837 | $1.3bn | 0.0% |
| FARALLON CAPITAL MANAGEMENT, L.L.C. | 6,348,906 | $778.2m | 3.6% |
| RTW INVESTMENTS, LP | 5,061,175 | $620.4m | 5.3% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 3,629,298 | $444.9m | 0.0% |
| WELLINGTON MANAGEMENT GROUP LLP | 3,416,781 | $418.8m | 0.1% |
| UBS Group AG | 3,399,221 | $416.7m | 0.1% |
| STATE STREET CORP | 3,321,554 | $407.2m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 2,853,394 | $349.8m | 0.0% |
| JOHNSON & JOHNSON | 2,449,183 | $300.2m | 37.6% |
| Invesco Ltd. | 2,340,667 | $286.9m | 0.0% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,149,662 | $263.5m | 0.0% |
| Jupiter Topco LLC | 2,129,780 | $261.0m | 0.1% |
| GEODE CAPITAL MANAGEMENT, LLC | 1,741,209 | $213.5m | 0.0% |
| Woodline Partners LP | 1,414,173 | $173.3m | 0.5% |
| BANK OF AMERICA CORP /DE/ | 1,324,498 | $162.4m | 0.0% |
| JENNISON ASSOCIATES LLC | 1,151,681 | $141.2m | 0.1% |
| PERCEPTIVE ADVISORS LLC | 981,879 | $120.4m | 1.8% |
| ADAR1 Capital Management, LLC | 960,863 | $117.8m | 5.4% |
| MORGAN STANLEY | 905,992 | $111.1m | 0.0% |
| Alyeska Investment Group, L.P. | 889,298 | $109.0m | 0.3% |
| Hood River Capital Management LLC | 882,738 | $108.2m | 0.8% |
| GOLDMAN SACHS GROUP INC | 812,852 | $99.6m | 0.0% |
| Driehaus Capital Management LLC | 731,053 | $89.6m | 0.5% |
| Clearbridge Investments, LLC | 725,335 | $88.9m | 0.1% |
| FMR LLC | 672,186 | $82.4m | 0.0% |