| BlackRock, Inc. | 10,654,276 | $355.7m | 0.0% |
| RTW INVESTMENTS, LP | 7,796,895 | $260.3m | 2.2% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 6,790,135 | $226.7m | 0.0% |
| AQR CAPITAL MANAGEMENT LLC | 6,560,809 | $214.1m | 0.1% |
| STATE STREET CORP | 6,158,766 | $205.6m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 4,296,491 | $143.5m | 0.0% |
| TWO SIGMA INVESTMENTS, LP | 3,621,200 | $120.9m | 0.1% |
| SANDS CAPITAL MANAGEMENT, LLC | 3,158,368 | $105.5m | 0.4% |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 2,939,719 | $98.2m | 0.4% |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 2,847,936 | $95.1m | 0.9% |
| GEODE CAPITAL MANAGEMENT, LLC | 2,578,828 | $86.1m | 0.0% |
| Bellevue Group AG | 1,982,775 | $66.2m | 1.4% |
| D. E. Shaw & Co., Inc. | 1,730,193 | $57.8m | 0.0% |
| Sofinnova Investments, Inc. | 1,717,505 | $57.3m | 3.0% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,580,000 | $52.8m | 0.1% |
| GW&K Investment Management, LLC | 1,481,178 | $49.5m | 0.4% |
| MPM BIOIMPACT LLC | 1,418,215 | $47.4m | 2.9% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,356,501 | $45.3m | 0.0% |
| MORGAN STANLEY | 1,324,805 | $44.2m | 0.0% |
| WELLINGTON MANAGEMENT GROUP LLP | 1,250,464 | $41.8m | 0.0% |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 1,241,556 | $41.5m | 0.2% |
| BANK OF AMERICA CORP /DE/ | 1,148,454 | $38.3m | 0.0% |
| Candriam S.C.A. | 1,001,841 | $33.4m | 0.2% |
| Rock Springs Capital Management LP | 967,855 | $32.3m | 1.6% |
| Jefferies Financial Group Inc. | 929,626 | $31.0m | 0.2% |