| SB INVESTMENT ADVISERS (UK) LTD | 27,904,963 | $522.1m | 6.8% |
| FMR LLC | 20,110,113 | $376.3m | 0.0% |
| Casdin Capital, LLC | 16,035,240 | $300.0m | 15.0% |
| BlackRock, Inc. | 15,288,202 | $286.0m | 0.0% |
| PERCEPTIVE ADVISORS LLC | 14,106,187 | $263.9m | 4.0% |
| Commodore Capital LP | 12,000,000 | $224.5m | 13.4% |
| STATE STREET CORP | 10,125,381 | $189.5m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 8,964,423 | $167.7m | 0.0% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 7,708,507 | $144.2m | 0.0% |
| Nextech Invest Ltd. | 6,776,506 | $126.8m | 6.0% |
| Bellevue Group AG | 6,185,970 | $115.7m | 2.4% |
| GEODE CAPITAL MANAGEMENT, LLC | 4,726,576 | $88.4m | 0.0% |
| TCG Crossover Management, LLC | 4,273,356 | $80.0m | 1.9% |
| MORGAN STANLEY | 3,851,071 | $72.1m | 0.0% |
| Siren, L.L.C. | 3,650,000 | $68.3m | 1.4% |
| GOLDMAN SACHS GROUP INC | 3,408,701 | $63.8m | 0.0% |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 3,343,496 | $62.6m | 0.2% |
| Kynam Capital Management, LP | 3,300,000 | $61.7m | 3.4% |
| DIMENSIONAL FUND ADVISORS LP | 3,127,564 | $58.5m | 0.0% |
| Spruce Street Capital LP | 2,984,125 | $55.8m | 11.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 2,892,785 | $54.1m | 0.0% |
| BAKER BROS. ADVISORS LP | 2,826,783 | $52.9m | 0.3% |
| BANK OF AMERICA CORP /DE/ | 2,695,108 | $50.4m | 0.0% |
| MPM BIOIMPACT LLC | 2,415,672 | $45.2m | 2.8% |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 2,238,929 | $41.9m | 0.0% |