| RA CAPITAL MANAGEMENT, L.P. | 9,905,045 | $435.7m | 3.8% |
| TPG GP A, LLC | 6,494,962 | $285.7m | 5.7% |
| VIKING GLOBAL INVESTORS LP | 3,195,181 | $140.6m | 0.4% |
| Atlas Venture Life Science Advisors, LLC | 2,995,602 | $131.8m | 15.0% |
| ORBIMED ADVISORS LLC | 2,555,877 | $112.4m | 2.1% |
| ENAVATE SCIENCES GP, LLC | 2,478,030 | $109.0m | 31.6% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,600,000 | $70.4m | 0.1% |
| BlackRock, Inc. | 1,474,769 | $64.9m | 0.0% |
| JPMORGAN CHASE & CO | 1,490,508 | $64.1m | 0.0% |
| JENNISON ASSOCIATES LLC | 1,172,133 | $51.6m | 0.0% |
| CITADEL ADVISORS LLC | 1,147,636 | $50.5m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 1,132,001 | $49.8m | 0.0% |
| STATE STREET CORP | 1,021,534 | $44.9m | 0.0% |
| PERCEPTIVE ADVISORS LLC | 905,000 | $39.8m | 0.6% |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 680,916 | $30.0m | 0.3% |
| Siren, L.L.C. | 610,515 | $26.9m | 0.5% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 478,016 | $21.0m | 0.0% |
| EVENTIDE ASSET MANAGEMENT, LLC | 474,981 | $20.9m | 0.3% |
| GEODE CAPITAL MANAGEMENT, LLC | 457,145 | $20.1m | 0.0% |
| BAKER BROS. ADVISORS LP | 400,000 | $17.6m | 0.1% |
| Casdin Capital, LLC | 400,000 | $17.6m | 0.9% |
| Kalehua Capital Management LLC | 394,144 | $17.3m | 5.5% |
| GOLDMAN SACHS GROUP INC | 388,810 | $17.1m | 0.0% |
| Driehaus Capital Management LLC | 385,447 | $17.0m | 0.1% |
| FRANKLIN RESOURCES INC | 290,113 | $12.8m | 0.0% |