| Siren, L.L.C. | 3,311,438 | $36.4m | 0.7% |
| TCG Crossover Management, LLC | 3,033,560 | $33.3m | 0.8% |
| Nantahala Capital Management, LLC | 2,693,462 | $29.6m | 0.5% |
| Redmile Group, LLC | 2,164,777 | $23.8m | 1.6% |
| CITADEL ADVISORS LLC | 1,329,625 | $14.6m | 0.0% |
| Nextech Invest Ltd. | 952,400 | $10.5m | 0.5% |
| MILLENNIUM MANAGEMENT LLC | 909,279 | $10.0m | 0.0% |
| Tetragon Partners GP Ltd | 764,256 | $8.4m | 1.3% |
| Soleus Capital Management, L.P. | 630,000 | $6.9m | 0.2% |
| Balyasny Asset Management L.P. | 610,980 | $6.7m | 0.0% |
| 5AM Venture Management, LLC | 476,200 | $5.2m | 1.8% |
| GREAT POINT PARTNERS LLC | 450,000 | $4.9m | 0.9% |
| MORGAN STANLEY | 403,172 | $4.4m | 0.0% |
| AMERIPRISE FINANCIAL INC | 370,052 | $4.1m | 0.0% |
| JANE STREET GROUP, LLC | 369,151 | $4.1m | 0.0% |
| ADAR1 Capital Management, LLC | 338,373 | $3.7m | 0.2% |
| SummitTX Capital, L.P. | 326,648 | $3.6m | 0.1% |
| Schonfeld Strategic Advisors LLC | 269,348 | $3.0m | 0.0% |
| UBS Group AG | 243,152 | $2.7m | 0.0% |
| Ishara Investments LP | 55,350 | $2.4m | 1.8% |
| BlackRock, Inc. | 219,917 | $2.4m | 0.0% |
| BANK OF MONTREAL /CAN/ | 201,734 | $2.2m | 0.0% |
| BOOTHBAY FUND MANAGEMENT, LLC | 198,347 | $2.2m | 0.0% |
| Propel Bio Management, LLC | 191,733 | $2.1m | 1.1% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 184,519 | $2.0m | 0.0% |