| RA CAPITAL MANAGEMENT, L.P. | 10,860,977 | $87.0m | 0.8% |
| Rubric Capital Management LP | 8,540,861 | $68.4m | 0.6% |
| ORBIMED ADVISORS LLC | 8,288,510 | $66.4m | 1.2% |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 7,503,812 | $60.1m | 0.6% |
| BlackRock, Inc. | 5,311,319 | $42.5m | 0.0% |
| Tyro Capital Management LLC | 4,459,337 | $35.7m | 8.0% |
| Aberdeen Group plc | 4,170,629 | $33.4m | 0.0% |
| SR One Capital Management, LP | 4,012,903 | $32.1m | 3.1% |
| STATE STREET CORP | 3,730,623 | $29.9m | 0.0% |
| Capital World Investors | 2,754,931 | $22.1m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 2,553,528 | $20.5m | 0.0% |
| MILLENNIUM MANAGEMENT LLC | 2,400,937 | $19.2m | 0.0% |
| Janney Montgomery Scott LLC | 2,064,498 | $16.5m | 0.0% |
| UBS Group AG | 1,939,654 | $15.5m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 1,699,017 | $13.6m | 0.0% |
| BOOTHBAY FUND MANAGEMENT, LLC | 1,601,504 | $12.8m | 0.2% |
| GENERAL AMERICAN INVESTORS CO INC | 1,133,046 | $9.1m | 0.5% |
| Third Point LLC | 1,000,000 | $8.0m | 0.2% |
| PEREGRINE CAPITAL MANAGEMENT LLC | 672,139 | $5.4m | 0.2% |
| Tejara Capital Ltd | 607,039 | $4.9m | 2.0% |
| ADAR1 Capital Management, LLC | 600,999 | $4.8m | 0.2% |
| Pavaki Capital Management LLC | 579,600 | $4.6m | 1.6% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 566,829 | $4.5m | 0.0% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 551,416 | $4.4m | 0.0% |
| NORTHERN TRUST CORP | 549,064 | $4.4m | 0.0% |