| BlackRock, Inc. | 9,350,046 | $434.9m | 0.0% |
| MILLENNIUM MANAGEMENT LLC | 3,853,212 | $179.2m | 0.1% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 3,305,429 | $153.7m | 0.0% |
| ARMISTICE CAPITAL, LLC | 2,646,201 | $123.1m | 1.5% |
| VANGUARD CAPITAL MANAGEMENT LLC | 2,516,721 | $117.1m | 0.0% |
| STATE STREET CORP | 2,459,828 | $114.4m | 0.0% |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 2,378,329 | $110.6m | 0.2% |
| DIMENSIONAL FUND ADVISORS LP | 2,078,090 | $96.7m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 1,570,088 | $73.0m | 0.0% |
| Stephens Investment Management Group LLC | 1,485,821 | $69.1m | 0.7% |
| RENAISSANCE TECHNOLOGIES LLC | 1,478,180 | $68.8m | 0.1% |
| LOOMIS SAYLES & CO L P | 1,475,192 | $68.6m | 0.1% |
| CITADEL ADVISORS LLC | 1,373,982 | $63.9m | 0.0% |
| TWO SIGMA INVESTMENTS, LP | 1,184,378 | $55.1m | 0.0% |
| GW&K Investment Management, LLC | 1,037,242 | $48.2m | 0.4% |
| Sofinnova Investments, Inc. | 1,036,328 | $48.2m | 2.5% |
| Qube Research & Technologies Ltd | 922,166 | $42.9m | 0.0% |
| MORGAN STANLEY | 876,841 | $40.8m | 0.0% |
| GOLDMAN SACHS GROUP INC | 819,432 | $38.1m | 0.0% |
| D. E. Shaw & Co., Inc. | 767,668 | $35.7m | 0.0% |
| NORTHERN TRUST CORP | 733,374 | $34.1m | 0.0% |
| Woodline Partners LP | 708,276 | $32.9m | 0.1% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 703,552 | $32.7m | 0.0% |
| BANK OF AMERICA CORP /DE/ | 621,102 | $28.9m | 0.0% |
| ASHFORD CAPITAL MANAGEMENT INC | 613,783 | $28.5m | 3.1% |