| Jupiter Topco LLC | 4,696,709 | $17.9m | 0.0% |
| BlackRock, Inc. | 3,663,499 | $14.0m | 0.0% |
| MILLENNIUM MANAGEMENT LLC | 3,101,166 | $11.8m | 0.0% |
| Velan Capital Investment Management LP | 2,844,652 | $10.9m | 6.6% |
| VANGUARD CAPITAL MANAGEMENT LLC | 2,300,133 | $8.8m | 0.0% |
| Blackstone Inc. | 2,265,514 | $8.7m | 0.0% |
| ORBIMED ADVISORS LLC | 2,220,000 | $8.5m | 0.2% |
| Sio Capital Management, LLC | 1,921,872 | $7.3m | 1.2% |
| ACORN CAPITAL ADVISORS, LLC | 1,752,115 | $6.7m | 1.8% |
| Integral Health Asset Management, LLC | 1,500,000 | $5.7m | 0.2% |
| 5AM Venture Management, LLC | 1,369,782 | $5.2m | 1.8% |
| GEODE CAPITAL MANAGEMENT, LLC | 1,326,246 | $5.1m | 0.0% |
| CITADEL ADVISORS LLC | 1,232,365 | $4.7m | 0.0% |
| STATE STREET CORP | 1,068,295 | $4.1m | 0.0% |
| Qube Research & Technologies Ltd | 1,045,516 | $4.0m | 0.0% |
| Balyasny Asset Management L.P. | 1,026,691 | $3.9m | 0.0% |
| BAKER BROS. ADVISORS LP | 971,614 | $3.7m | 0.0% |
| ADAR1 Capital Management, LLC | 940,512 | $3.6m | 0.2% |
| BANK OF AMERICA CORP /DE/ | 882,179 | $3.4m | 0.0% |
| MARSHALL WACE, LLP | 701,021 | $2.7m | 0.0% |
| DIMENSIONAL FUND ADVISORS LP | 683,230 | $2.6m | 0.0% |
| NORTHERN TRUST CORP | 552,306 | $2.1m | 0.0% |
| Point72 Asset Management, L.P. | 548,932 | $2.1m | 0.0% |
| GOLDMAN SACHS GROUP INC | 546,227 | $2.1m | 0.0% |
| Catalio Capital Management, LP | 520,148 | $2.0m | 0.4% |