| BlackRock, Inc. | 22,050,045 | $1.2bn | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 7,963,266 | $437.5m | 0.0% |
| STATE STREET CORP | 7,786,471 | $427.8m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 6,149,403 | $337.8m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 3,642,216 | $200.1m | 0.0% |
| D. E. Shaw & Co., Inc. | 3,400,808 | $186.8m | 0.1% |
| Soleus Capital Management, L.P. | 2,927,895 | $160.9m | 5.5% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,767,656 | $152.1m | 0.0% |
| Clearbridge Investments, LLC | 2,650,192 | $145.6m | 0.1% |
| CONGRESS ASSET MANAGEMENT CO | 2,600,123 | $142.9m | 0.9% |
| TWO SIGMA INVESTMENTS, LP | 2,468,971 | $135.6m | 0.1% |
| GOLDMAN SACHS GROUP INC | 2,314,279 | $127.1m | 0.0% |
| Pictet Asset Management Holding SA | 1,785,951 | $98.1m | 0.1% |
| JANE STREET GROUP, LLC | 1,752,646 | $96.3m | 0.0% |
| Nuveen, LLC | 1,625,876 | $89.3m | 0.0% |
| MORGAN STANLEY | 1,601,714 | $88.0m | 0.0% |
| Hood River Capital Management LLC | 1,600,510 | $87.9m | 0.6% |
| NORTHERN TRUST CORP | 1,537,059 | $84.4m | 0.0% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,313,103 | $72.1m | 0.0% |
| BANK OF AMERICA CORP /DE/ | 1,309,788 | $72.0m | 0.0% |
| DIMENSIONAL FUND ADVISORS LP | 1,210,578 | $66.5m | 0.0% |
| FMR LLC | 1,018,814 | $56.0m | 0.0% |
| VANGUARD FIDUCIARY TRUST CO | 961,750 | $52.8m | 0.0% |
| BARCLAYS PLC | 957,848 | $52.6m | 0.0% |
| Bank of New York Mellon Corp | 900,482 | $49.5m | 0.0% |