| BlackRock, Inc. | 5,596,549 | $371.7m | 0.0% |
| FMR LLC | 5,133,328 | $341.0m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 1,933,989 | $128.5m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 1,497,600 | $99.5m | 0.0% |
| STATE STREET CORP | 1,420,421 | $94.3m | 0.0% |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 910,495 | $60.5m | 0.1% |
| GEODE CAPITAL MANAGEMENT, LLC | 894,913 | $59.5m | 0.0% |
| Hood River Capital Management LLC | 751,133 | $49.9m | 0.4% |
| DIMENSIONAL FUND ADVISORS LP | 610,107 | $40.5m | 0.0% |
| BRAIDWELL LP | 609,715 | $40.5m | 1.5% |
| GOLDMAN SACHS GROUP INC | 559,771 | $37.2m | 0.0% |
| CITADEL ADVISORS LLC | 558,824 | $37.1m | 0.0% |
| EVENTIDE ASSET MANAGEMENT, LLC | 548,874 | $36.5m | 0.5% |
| WELLINGTON MANAGEMENT GROUP LLP | 515,973 | $34.3m | 0.0% |
| EMERALD ADVISERS, LLC | 490,491 | $32.6m | 0.8% |
| UBS Group AG | 488,058 | $32.4m | 0.0% |
| MORGAN STANLEY | 405,112 | $26.9m | 0.0% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 398,250 | $26.5m | 0.0% |
| Invesco Ltd. | 394,979 | $26.2m | 0.0% |
| CITIGROUP INC | 386,066 | $25.6m | 0.0% |
| Capital World Investors | 384,671 | $25.5m | 0.0% |
| NORTHERN TRUST CORP | 368,860 | $24.5m | 0.0% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 328,666 | $21.8m | 0.0% |
| WASATCH ADVISORS LP | 308,434 | $20.5m | 0.1% |
| ZEVENBERGEN CAPITAL INVESTMENTS LLC | 308,391 | $20.5m | 0.5% |