| NEA Management Company, LLC | 13,222,228 | $246.6m | 15.5% |
| FMR LLC | 12,562,839 | $234.3m | 0.0% |
| BlackRock, Inc. | 11,155,026 | $208.0m | 0.0% |
| Frazier Life Sciences Management, L.P. | 9,939,447 | $185.4m | 4.0% |
| WELLINGTON MANAGEMENT GROUP LLP | 5,684,592 | $106.0m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 5,530,675 | $103.1m | 0.0% |
| Vivo Capital, LLC | 5,094,668 | $95.0m | 8.7% |
| Woodline Partners LP | 4,081,333 | $76.1m | 0.2% |
| Vestal Point Capital, LP | 3,100,000 | $57.8m | 1.4% |
| MPM BIOIMPACT LLC | 3,073,577 | $57.3m | 3.5% |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 3,070,740 | $57.3m | 0.5% |
| Assenagon Asset Management S.A. | 3,050,628 | $56.9m | 0.0% |
| STATE STREET CORP | 3,027,315 | $56.5m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 2,928,068 | $54.6m | 0.0% |
| MARSHALL WACE, LLP | 2,674,137 | $49.9m | 0.0% |
| EVENTIDE ASSET MANAGEMENT, LLC | 2,660,000 | $49.6m | 0.7% |
| Rubric Capital Management LP | 2,504,513 | $46.7m | 0.4% |
| Artia Global Partners LP | 2,210,852 | $41.2m | 7.6% |
| ACORN CAPITAL ADVISORS, LLC | 2,144,844 | $40.0m | 10.9% |
| First Light Asset Management, LLC | 2,097,215 | $39.1m | 2.4% |
| Pictet Asset Management Holding SA | 2,013,786 | $37.6m | 0.0% |
| Logos Global Management LP | 1,880,000 | $35.1m | 1.5% |
| Affinity Asset Advisors, LLC | 1,800,172 | $33.6m | 1.5% |
| EMERALD ADVISERS, LLC | 1,797,611 | $33.5m | 0.8% |
| Siren, L.L.C. | 1,786,867 | $33.3m | 0.7% |