| FMR LLC | 8,162,897 | $56.5m | 0.0% |
| ORBIMED ADVISORS LLC | 5,693,589 | $39.4m | 0.7% |
| NORGES BANK | 3,768,619 | $26.1m | 0.0% |
| BlackRock, Inc. | 3,753,358 | $26.0m | 0.0% |
| Decheng Capital LLC | 2,724,868 | $18.9m | 2.6% |
| ENAVATE SCIENCES GP, LLC | 2,459,703 | $17.0m | 4.9% |
| VANGUARD CAPITAL MANAGEMENT LLC | 1,876,734 | $13.0m | 0.0% |
| MILLENNIUM MANAGEMENT LLC | 1,143,775 | $7.9m | 0.0% |
| D. E. Shaw & Co., Inc. | 1,036,044 | $7.2m | 0.0% |
| JPMORGAN CHASE & CO | 1,012,044 | $7.0m | 0.0% |
| Qube Research & Technologies Ltd | 978,500 | $6.8m | 0.0% |
| Parkman Healthcare Partners LLC | 935,247 | $6.5m | 0.7% |
| GEODE CAPITAL MANAGEMENT, LLC | 931,261 | $6.4m | 0.0% |
| SEB Asset Management AB | 878,473 | $6.1m | 0.0% |
| Woodline Partners LP | 831,481 | $5.8m | 0.0% |
| STATE STREET CORP | 766,323 | $5.3m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 712,667 | $4.9m | 0.0% |
| Y-Intercept (Hong Kong) Ltd | 693,555 | $4.8m | 0.1% |
| Bain Capital Life Sciences Investors, LLC | 600,949 | $4.2m | 0.2% |
| AQR CAPITAL MANAGEMENT LLC | 544,869 | $3.8m | 0.0% |
| MORGAN STANLEY | 524,632 | $3.6m | 0.0% |
| BNP PARIBAS FINANCIAL MARKETS | 511,546 | $3.5m | 0.0% |
| Walleye Capital LLC | 498,490 | $3.4m | 0.0% |
| Trexquant Investment LP | 466,430 | $3.2m | 0.0% |
| Point72 Asset Management, L.P. | 453,011 | $3.1m | 0.0% |