| BlackRock, Inc. | 13,651,261 | $219.8m | 0.0% |
| PRIMECAP MANAGEMENT CO/CA/ | 10,181,322 | $163.9m | 0.1% |
| BVF INC/IL | 7,133,720 | $114.9m | 2.9% |
| RTW INVESTMENTS, LP | 6,777,461 | $109.1m | 0.9% |
| RA CAPITAL MANAGEMENT, L.P. | 5,274,274 | $84.9m | 0.7% |
| STATE STREET CORP | 4,954,016 | $79.8m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 3,278,802 | $52.8m | 0.0% |
| TCG Crossover Management, LLC | 2,452,138 | $39.5m | 0.9% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,356,409 | $37.9m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 2,215,690 | $35.7m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 1,920,859 | $30.9m | 0.0% |
| MORGAN STANLEY | 1,752,556 | $28.2m | 0.0% |
| UBS Group AG | 1,306,174 | $21.0m | 0.0% |
| BAKER BROS. ADVISORS LP | 1,102,106 | $17.7m | 0.1% |
| Legal & General Group Plc | 1,091,177 | $17.6m | 0.0% |
| DIMENSIONAL FUND ADVISORS LP | 1,011,119 | $16.3m | 0.0% |
| GOLDMAN SACHS GROUP INC | 968,778 | $15.6m | 0.0% |
| MILLENNIUM MANAGEMENT LLC | 853,677 | $13.7m | 0.0% |
| TWO SIGMA INVESTMENTS, LP | 819,515 | $13.2m | 0.0% |
| NORTHERN TRUST CORP | 794,279 | $12.8m | 0.0% |
| JOHNSON & JOHNSON | 748,062 | $12.0m | 1.5% |
| Jefferies Financial Group Inc. | 720,440 | $11.6m | 0.1% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 707,242 | $11.4m | 0.0% |
| PANAGORA ASSET MANAGEMENT INC | 680,182 | $11.0m | 0.0% |
| Deep Track Capital, LP | 593,551 | $9.6m | 0.1% |