| FMR LLC | 9,506,701 | $241.3m | 0.0% |
| SR One Capital Management, LP | 5,037,854 | $127.9m | 12.3% |
| NEA Management Company, LLC | 4,023,219 | $102.1m | 6.4% |
| ENAVATE SCIENCES GP, LLC | 3,919,159 | $99.5m | 28.8% |
| FEDERATED HERMES, INC. | 3,116,805 | $79.1m | 0.1% |
| BlackRock, Inc. | 2,686,225 | $68.2m | 0.0% |
| Capital International Investors | 2,502,912 | $63.5m | 0.0% |
| Polar Capital Holdings Plc | 2,412,772 | $61.2m | 0.1% |
| Royalty Pharma Sub-Manager, LLC | 2,388,150 | $60.6m | 25.1% |
| Fairmount Funds Management LLC | 2,359,025 | $59.9m | 4.0% |
| STATE STREET CORP | 2,055,100 | $52.2m | 0.0% |
| NVP ASSOCIATES, LLC | 1,838,482 | $46.7m | 14.2% |
| WELLINGTON MANAGEMENT GROUP LLP | 1,593,819 | $40.5m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 1,354,864 | $34.4m | 0.0% |
| BANK OF AMERICA CORP /DE/ | 1,231,159 | $31.2m | 0.0% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,226,928 | $31.1m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 882,654 | $22.4m | 0.0% |
| ALLIANCEBERNSTEIN L.P. | 1,103,388 | $21.6m | 0.0% |
| TWO SIGMA INVESTMENTS, LP | 815,150 | $20.7m | 0.0% |
| EcoR1 Capital, LLC | 789,500 | $20.0m | 1.0% |
| MILLENNIUM MANAGEMENT LLC | 660,470 | $16.8m | 0.0% |
| Woodline Partners LP | 590,539 | $15.0m | 0.0% |
| Balyasny Asset Management L.P. | 576,717 | $14.6m | 0.0% |
| ArrowMark Colorado Holdings LLC | 573,318 | $14.6m | 0.6% |
| SILVERARC CAPITAL MANAGEMENT, LLC | 509,789 | $12.9m | 1.3% |