| EcoR1 Capital, LLC | 22,970,388 | $600.4m | 29.2% |
| Rubric Capital Management LP | 7,000,000 | $183.0m | 1.7% |
| BlackRock, Inc. | 4,251,030 | $111.1m | 0.0% |
| PERCEPTIVE ADVISORS LLC | 4,182,953 | $109.3m | 1.6% |
| BVF INC/IL | 3,649,142 | $95.4m | 2.4% |
| Assenagon Asset Management S.A. | 2,504,054 | $65.5m | 0.0% |
| MORGAN STANLEY | 2,231,260 | $58.3m | 0.0% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 1,781,116 | $46.6m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 1,558,998 | $40.8m | 0.0% |
| Nextech Invest Ltd. | 1,113,946 | $29.1m | 1.4% |
| STATE STREET CORP | 1,088,216 | $28.4m | 0.0% |
| DIMENSIONAL FUND ADVISORS LP | 994,955 | $26.0m | 0.0% |
| CITADEL ADVISORS LLC | 914,136 | $23.9m | 0.0% |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 889,802 | $23.3m | 0.0% |
| FMR LLC | 702,568 | $18.4m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 692,410 | $18.1m | 0.0% |
| Prosight Management, LP | 674,434 | $17.6m | 3.0% |
| Qube Research & Technologies Ltd | 593,590 | $15.5m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 510,032 | $13.3m | 0.0% |
| Redmile Group, LLC | 491,654 | $12.9m | 0.9% |
| Capricorn Fund Managers Ltd | 486,529 | $12.7m | 1.0% |
| GOLDMAN SACHS GROUP INC | 470,822 | $12.3m | 0.0% |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 418,497 | $10.9m | 0.0% |
| DEUTSCHE BANK AG\ | 397,190 | $10.4m | 0.0% |
| Hillsdale Investment Management Inc. | 382,922 | $10.0m | 0.2% |