| BAKER BROS. ADVISORS LP | 33,012,138 | $259.1m | 1.3% |
| Capital World Investors | 13,588,349 | $106.7m | 0.0% |
| TWO SIGMA INVESTMENTS, LP | 10,437,431 | $81.9m | 0.1% |
| TD Waterhouse Canada Inc. | 9,568,149 | $72.6m | 0.2% |
| BANK OF AMERICA CORP /DE/ | 6,141,539 | $48.2m | 0.0% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 4,317,206 | $33.9m | 0.0% |
| ArrowMark Colorado Holdings LLC | 4,105,095 | $32.2m | 1.3% |
| BlackRock, Inc. | 3,805,309 | $29.9m | 0.0% |
| Driehaus Capital Management LLC | 2,864,729 | $22.5m | 0.1% |
| TUDOR INVESTMENT CORP ET AL | 2,063,191 | $16.2m | 0.0% |
| MARSHALL WACE, LLP | 1,902,191 | $14.9m | 0.0% |
| UBS Group AG | 1,870,633 | $14.7m | 0.0% |
| MORGAN STANLEY | 1,669,014 | $13.1m | 0.0% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,587,870 | $12.5m | 0.0% |
| CITADEL ADVISORS LLC | 1,586,512 | $12.5m | 0.0% |
| NATIONAL BANK OF CANADA /FI/ | 1,233,014 | $9.7m | 0.0% |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 1,039,927 | $8.2m | 0.0% |
| RENAISSANCE TECHNOLOGIES LLC | 990,929 | $7.8m | 0.0% |
| Counterpoint Mutual Funds LLC | 971,643 | $7.6m | 0.8% |
| STATE STREET CORP | 731,362 | $5.7m | 0.0% |
| HRT FINANCIAL LP | 705,506 | $5.5m | 0.0% |
| DNB Asset Management AS | 677,479 | $5.3m | 0.0% |
| Guardian Partners Inc. | 595,998 | $4.7m | 0.4% |
| Intellectus Partners, LLC | 551,583 | $4.3m | 0.7% |
| Alyeska Investment Group, L.P. | 526,577 | $4.1m | 0.0% |