| Nantahala Capital Management, LLC | 10,272,980 | $63.5m | 1.1% |
| BlackRock, Inc. | 3,352,474 | $20.7m | 0.0% |
| Cable Car Capital, LP | 3,007,329 | $18.6m | 0.4% |
| AIGH Capital Management LLC | 2,987,000 | $18.5m | 1.2% |
| VANGUARD CAPITAL MANAGEMENT LLC | 2,211,433 | $13.7m | 0.0% |
| OneDigital Investment Advisors LLC | 1,653,024 | $10.2m | 0.1% |
| AWM Investment Company, Inc. | 1,486,130 | $9.2m | 0.8% |
| GEODE CAPITAL MANAGEMENT, LLC | 1,261,090 | $7.8m | 0.0% |
| KENNEDY CAPITAL MANAGEMENT LLC | 1,240,071 | $7.7m | 0.1% |
| GOLDMAN SACHS GROUP INC | 1,224,806 | $7.6m | 0.0% |
| STATE STREET CORP | 1,040,228 | $6.4m | 0.0% |
| Propel Bio Management, LLC | 983,070 | $6.1m | 3.2% |
| NAN FUNG TRINITY (HK) LTD | 956,770 | $5.9m | 0.6% |
| Diametric Capital, LP | 755,021 | $4.7m | 0.5% |
| J. Goldman & Co LP | 678,173 | $4.2m | 0.1% |
| SILVERARC CAPITAL MANAGEMENT, LLC | 610,407 | $3.8m | 0.4% |
| Rubric Capital Management LP | 608,771 | $3.8m | 0.0% |
| Stonepine Capital Management, LLC | 557,284 | $3.4m | 0.9% |
| NORTHERN TRUST CORP | 552,630 | $3.4m | 0.0% |
| CITIGROUP INC | 548,300 | $3.4m | 0.0% |
| MONTANOVA CAPITAL, LLC | 500,000 | $3.1m | 0.1% |
| NATIONAL BANK OF CANADA /FI/ | 500,000 | $3.1m | 0.0% |
| Knoll Capital Management, LLC | 485,515 | $3.0m | 1.7% |
| PANAGORA ASSET MANAGEMENT INC | 409,075 | $2.5m | 0.0% |
| BANK OF AMERICA CORP /DE/ | 372,406 | $2.3m | 0.0% |