| FMR LLC | 25,410,048 | $294.5m | 0.0% |
| ARK Investment Management LLC | 12,925,271 | $149.8m | 1.0% |
| BlackRock, Inc. | 12,175,302 | $141.1m | 0.0% |
| STATE STREET CORP | 8,097,308 | $93.8m | 0.0% |
| AMERIPRISE FINANCIAL INC | 6,991,763 | $81.0m | 0.0% |
| Redmile Group, LLC | 6,739,675 | $78.1m | 5.2% |
| VANGUARD CAPITAL MANAGEMENT LLC | 6,122,677 | $71.0m | 0.0% |
| ADVANCED MICRO DEVICES INC | 5,714,285 | $66.2m | 5.0% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 5,704,820 | $66.1m | 0.1% |
| TWO SIGMA INVESTMENTS, LP | 5,493,486 | $63.7m | 0.0% |
| D. E. Shaw & Co., Inc. | 5,239,754 | $60.7m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 3,583,163 | $41.5m | 0.0% |
| Woodline Partners LP | 2,700,675 | $31.3m | 0.1% |
| Siren, L.L.C. | 2,474,764 | $28.7m | 0.6% |
| BVF INC/IL | 2,361,674 | $27.4m | 0.7% |
| Gem Investment Advisors, LLC | 2,170,863 | $25.2m | 15.4% |
| BAKER BROS. ADVISORS LP | 2,134,803 | $24.7m | 0.1% |
| GOLDMAN SACHS GROUP INC | 1,732,324 | $20.1m | 0.0% |
| Nuveen, LLC | 1,723,979 | $20.0m | 0.0% |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 1,602,916 | $18.6m | 0.1% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,489,993 | $17.3m | 0.0% |
| MORGAN STANLEY | 1,374,693 | $15.9m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 1,339,024 | $15.5m | 0.0% |
| FRED ALGER MANAGEMENT, LLC | 1,176,797 | $13.6m | 0.0% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,165,995 | $13.5m | 0.0% |