| BlackRock, Inc. | 2,958,646 | $244.9m | 0.0% |
| Soleus Capital Management, L.P. | 867,760 | $71.8m | 2.5% |
| VANGUARD CAPITAL MANAGEMENT LLC | 838,224 | $69.4m | 0.0% |
| STATE STREET CORP | 831,647 | $68.9m | 0.0% |
| TANG CAPITAL MANAGEMENT LLC | 707,500 | $58.6m | 2.7% |
| DIMENSIONAL FUND ADVISORS LP | 623,463 | $51.6m | 0.0% |
| AMERICAN CENTURY COMPANIES INC | 574,474 | $47.6m | 0.0% |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 562,016 | $46.5m | 0.0% |
| Global Alpha Capital Management Ltd. | 558,003 | $46.2m | 2.8% |
| GEODE CAPITAL MANAGEMENT, LLC | 536,407 | $44.4m | 0.0% |
| MILLENNIUM MANAGEMENT LLC | 507,207 | $42.0m | 0.0% |
| Nuveen, LLC | 415,024 | $34.4m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 407,281 | $33.7m | 0.0% |
| Ranger Investment Management, L.P. | 343,150 | $28.4m | 1.8% |
| DEUTSCHE BANK AG\ | 323,443 | $26.8m | 0.0% |
| Invesco Ltd. | 309,233 | $25.6m | 0.0% |
| UBS Group AG | 297,539 | $24.6m | 0.0% |
| KENNEDY CAPITAL MANAGEMENT LLC | 295,938 | $24.5m | 0.4% |
| AMERIPRISE FINANCIAL INC | 287,382 | $23.8m | 0.0% |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 287,206 | $23.8m | 0.0% |
| Ikarian Capital, LLC | 272,085 | $22.5m | 2.4% |
| Aberdeen Group plc | 271,760 | $22.5m | 0.0% |
| OBERWEIS ASSET MANAGEMENT INC/ | 265,306 | $22.0m | 0.5% |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 258,173 | $21.4m | 0.1% |
| Rubric Capital Management LP | 258,131 | $21.4m | 0.2% |