| TANG CAPITAL MANAGEMENT LLC | 13,044,106 | $221.4m | 10.1% |
| BlackRock, Inc. | 8,193,085 | $139.0m | 0.0% |
| GOLDMAN SACHS GROUP INC | 5,619,401 | $95.4m | 0.0% |
| NEA Management Company, LLC | 3,969,834 | $67.4m | 4.2% |
| TWO SIGMA INVESTMENTS, LP | 3,467,514 | $58.8m | 0.0% |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 3,264,062 | $55.4m | 0.0% |
| STATE STREET CORP | 2,589,615 | $43.9m | 0.0% |
| MORGAN STANLEY | 2,308,244 | $39.2m | 0.0% |
| MARSHALL WACE, LLP | 2,044,007 | $34.7m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 1,701,152 | $28.9m | 0.0% |
| RENAISSANCE TECHNOLOGIES LLC | 1,548,035 | $26.3m | 0.0% |
| D. E. Shaw & Co., Inc. | 1,408,456 | $23.9m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 1,359,028 | $23.1m | 0.0% |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 1,231,516 | $20.9m | 0.1% |
| JUPITER ASSET MANAGEMENT LTD | 1,094,475 | $18.6m | 0.1% |
| LSV ASSET MANAGEMENT | 1,079,447 | $18.3m | 0.0% |
| NOMURA HOLDINGS INC | 978,602 | $16.6m | 0.0% |
| AQR CAPITAL MANAGEMENT LLC | 948,751 | $16.1m | 0.0% |
| NORTHERN TRUST CORP | 863,567 | $14.7m | 0.0% |
| Nuveen, LLC | 812,915 | $13.8m | 0.0% |
| Jupiter Topco LLC | 602,195 | $10.2m | 0.0% |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | 596,618 | $10.1m | 0.0% |
| PRUDENTIAL FINANCIAL INC | 582,345 | $9.9m | 0.0% |
| O'SHAUGHNESSY ASSET MANAGEMENT, LLC | 567,492 | $9.6m | 0.0% |
| Hillsdale Investment Management Inc. | 550,900 | $9.3m | 0.2% |