| MAK CAPITAL ONE LLC | 33,621,487 | $53.8m | 7.5% |
| Blackstone Inc. | 20,485,611 | $32.8m | 0.1% |
| Syncona Portfolio Ltd | 16,640,720 | $26.6m | 100.0% |
| ARMISTICE CAPITAL, LLC | 15,000,000 | $24.0m | 0.3% |
| Tetragon Partners GP Ltd | 9,500,000 | $15.2m | 2.4% |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 7,833,282 | $12.9m | 0.0% |
| Frazier Life Sciences Management, L.P. | 4,447,910 | $7.1m | 0.2% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 3,361,156 | $5.4m | 0.0% |
| Laurion Capital Management LP | 3,316,626 | $5.3m | 0.1% |
| RENAISSANCE TECHNOLOGIES LLC | 1,984,700 | $3.2m | 0.0% |
| BANK OF AMERICA CORP /DE/ | 1,605,092 | $2.6m | 0.0% |
| BlackRock, Inc. | 1,603,458 | $2.6m | 0.0% |
| UBS Group AG | 1,516,991 | $2.4m | 0.0% |
| MORGAN STANLEY | 1,260,832 | $2.0m | 0.0% |
| MILLENNIUM MANAGEMENT LLC | 1,224,818 | $2.0m | 0.0% |
| Cetera Investment Advisers | 1,157,324 | $1.9m | 0.0% |
| Balyasny Asset Management L.P. | 972,748 | $1.6m | 0.0% |
| JPMORGAN CHASE & CO | 913,239 | $1.5m | 0.0% |
| Alphabet Inc. | 698,262 | $1.1m | 0.0% |
| CITADEL ADVISORS LLC | 695,890 | $1.1m | 0.0% |
| Hennion & Walsh Asset Management, Inc. | 451,403 | $722,245 | 0.0% |
| Privium Fund Management B.V. | 363,430 | $581,488 | 0.1% |
| JANE STREET GROUP, LLC | 299,862 | $479,779 | 0.0% |
| EDENTREE ASSET MANAGEMENT Ltd | 300,000 | $477,000 | 0.1% |
| XTX Topco Ltd | 287,456 | $459,930 | 0.0% |