| FMR LLC | 12,004,064 | $55.8m | 0.0% |
| BlackRock, Inc. | 8,720,077 | $40.5m | 0.0% |
| BML Capital Management, LLC | 6,952,330 | $32.3m | 18.4% |
| TANG CAPITAL MANAGEMENT LLC | 4,814,700 | $22.4m | 1.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 2,964,862 | $13.8m | 0.0% |
| Bain Capital Life Sciences Investors, LLC | 2,075,639 | $9.7m | 0.6% |
| ACADIAN ASSET MANAGEMENT LLC | 2,035,192 | $9.5m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 1,958,435 | $9.1m | 0.0% |
| STATE STREET CORP | 1,652,399 | $7.7m | 0.0% |
| TWO SIGMA INVESTMENTS, LP | 1,506,697 | $7.0m | 0.0% |
| DIMENSIONAL FUND ADVISORS LP | 1,299,515 | $6.0m | 0.0% |
| RENAISSANCE TECHNOLOGIES LLC | 1,131,200 | $5.3m | 0.0% |
| Rosalind Advisors, Inc. | 1,070,550 | $5.0m | 1.8% |
| JPMORGAN CHASE & CO | 945,918 | $4.4m | 0.0% |
| NORTHERN TRUST CORP | 755,239 | $3.5m | 0.0% |
| MORGAN STANLEY | 719,514 | $3.3m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 630,185 | $2.9m | 0.0% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 610,607 | $2.8m | 0.0% |
| GOLDMAN SACHS GROUP INC | 530,856 | $2.5m | 0.0% |
| VANGUARD FIDUCIARY TRUST CO | 469,801 | $2.2m | 0.0% |
| CM Management, LLC | 355,000 | $1.7m | 1.0% |
| BARCLAYS PLC | 348,653 | $1.6m | 0.0% |
| D. E. Shaw & Co., Inc. | 345,186 | $1.6m | 0.0% |
| BANQUE PICTET & CIE SA | 345,077 | $1.6m | 0.0% |
| MILLENNIUM MANAGEMENT LLC | 304,611 | $1.4m | 0.0% |