| FMR LLC | 5,100,216 | $94.3m | 0.0% |
| BlackRock, Inc. | 4,365,553 | $80.7m | 0.0% |
| Nantahala Capital Management, LLC | 3,724,500 | $68.8m | 1.1% |
| Deep Track Capital, LP | 3,610,000 | $66.7m | 1.0% |
| Caligan Partners LP | 3,163,866 | $58.5m | 2.8% |
| TCG Crossover Management, LLC | 3,017,120 | $55.8m | 1.3% |
| Affinity Asset Advisors, LLC | 2,900,000 | $53.6m | 2.4% |
| STATE STREET CORP | 2,889,287 | $53.4m | 0.0% |
| FARALLON CAPITAL MANAGEMENT, L.L.C. | 2,498,000 | $46.2m | 0.2% |
| Point72 Asset Management, L.P. | 2,387,026 | $44.1m | 0.0% |
| Avoro Capital Advisors LLC | 2,333,333 | $43.1m | 0.4% |
| VANGUARD CAPITAL MANAGEMENT LLC | 2,264,246 | $41.8m | 0.0% |
| BVF INC/IL | 2,075,545 | $38.4m | 1.0% |
| BANK OF AMERICA CORP /DE/ | 1,913,829 | $35.4m | 0.0% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,729,000 | $32.0m | 0.0% |
| Soleus Capital Management, L.P. | 1,654,978 | $30.6m | 1.1% |
| BRAIDWELL LP | 1,629,182 | $30.1m | 1.1% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,311,715 | $24.2m | 0.0% |
| ALLIANCEBERNSTEIN L.P. | 1,260,689 | $23.3m | 0.0% |
| UBS Group AG | 1,209,059 | $22.3m | 0.0% |
| Logos Global Management LP | 1,150,000 | $21.3m | 0.9% |
| GEODE CAPITAL MANAGEMENT, LLC | 1,105,118 | $20.4m | 0.0% |
| Commodore Capital LP | 1,018,319 | $18.8m | 1.1% |
| RA CAPITAL MANAGEMENT, L.P. | 1,000,000 | $18.5m | 0.2% |
| GOLDMAN SACHS GROUP INC | 946,320 | $17.5m | 0.0% |