| Cormorant Asset Management, LP | 17,878,594 | $136.2m | 7.0% |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 4,885,446 | $37.2m | 0.4% |
| Omega Fund Management, LLC | 3,289,661 | $25.1m | 13.5% |
| EcoR1 Capital, LLC | 2,823,126 | $21.5m | 1.0% |
| Alphabet Inc. | 2,823,126 | $21.5m | 0.0% |
| WELLINGTON MANAGEMENT GROUP LLP | 2,789,302 | $21.3m | 0.0% |
| ENAVATE SCIENCES GP, LLC | 2,626,946 | $20.0m | 5.8% |
| CITADEL ADVISORS LLC | 2,617,827 | $19.9m | 0.0% |
| NOVO HOLDINGS A/S | 2,250,000 | $17.1m | 1.0% |
| BlackRock, Inc. | 2,154,040 | $16.4m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 2,005,649 | $15.3m | 0.0% |
| Laurion Capital Management LP | 2,002,701 | $15.3m | 0.4% |
| ARMISTICE CAPITAL, LLC | 1,764,000 | $13.4m | 0.2% |
| STATE STREET CORP | 1,036,569 | $7.9m | 0.0% |
| Aisling Capital Management LP | 1,018,018 | $7.8m | 1.6% |
| Opaleye Management Inc. | 700,000 | $5.3m | 0.5% |
| GEODE CAPITAL MANAGEMENT, LLC | 622,351 | $4.7m | 0.0% |
| Granahan Investment Management, LLC | 558,526 | $4.3m | 0.2% |
| SPHERA FUNDS MANAGEMENT LTD. | 460,985 | $3.5m | 0.5% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 400,000 | $3.0m | 0.0% |
| ROYCE & ASSOCIATES LP | 384,941 | $2.9m | 0.0% |
| Catalio Capital Management, LP | 318,407 | $2.4m | 0.5% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 300,000 | $2.3m | 0.0% |
| VANGUARD FIDUCIARY TRUST CO | 291,522 | $2.2m | 0.0% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 286,518 | $2.2m | 0.0% |