| a16z Capital Management, L.L.C. | 3,233,170 | $79.2m | 0.6% |
| BlackRock, Inc. | 2,849,077 | $69.8m | 0.0% |
| Cormorant Asset Management, LP | 2,390,605 | $58.6m | 3.0% |
| Sofinnova Investments, Inc. | 2,293,788 | $56.2m | 2.9% |
| Jupiter Topco LLC | 2,144,633 | $52.6m | 0.0% |
| Octagon Capital Advisors LP | 1,748,000 | $42.8m | 3.9% |
| RA CAPITAL MANAGEMENT, L.P. | 1,671,648 | $41.0m | 0.4% |
| MPM BIOIMPACT LLC | 1,667,661 | $40.9m | 2.5% |
| VANGUARD CAPITAL MANAGEMENT LLC | 1,544,214 | $37.8m | 0.0% |
| Polar Capital Holdings Plc | 1,072,344 | $26.3m | 0.1% |
| BRAIDWELL LP | 1,033,129 | $25.3m | 0.9% |
| STATE STREET CORP | 1,021,464 | $25.0m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 1,004,264 | $24.6m | 0.0% |
| Sands Capital Alternatives, LLC | 786,353 | $19.3m | 3.1% |
| ORBIMED ADVISORS LLC | 752,153 | $18.4m | 0.3% |
| D. E. Shaw & Co., Inc. | 742,761 | $18.2m | 0.0% |
| Balyasny Asset Management L.P. | 702,858 | $17.2m | 0.0% |
| Pivotal bioVenture Partners Investment Advisor LLC | 653,374 | $16.0m | 5.2% |
| COSMIC MANAGEMENT, LLC | 501,833 | $12.3m | 3.2% |
| STEMPOINT CAPITAL LP | 464,171 | $11.4m | 2.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 410,165 | $10.1m | 0.0% |
| DIMENSIONAL FUND ADVISORS LP | 394,138 | $9.7m | 0.0% |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 377,085 | $9.2m | 0.0% |
| Walleye Capital LLC | 354,395 | $8.7m | 0.0% |
| Nuveen, LLC | 349,142 | $8.6m | 0.0% |