| JENNISON ASSOCIATES LLC | 20,033,730 | $62.3m | 0.0% |
| T. Rowe Price Investment Management, Inc. | 18,869,907 | $58.7m | 0.0% |
| Bain Capital Life Sciences Investors, LLC | 17,241,445 | $53.6m | 3.2% |
| BlackRock, Inc. | 10,754,701 | $33.4m | 0.0% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 9,174,758 | $28.5m | 0.0% |
| STATE STREET CORP | 7,839,305 | $24.4m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 7,227,018 | $22.5m | 0.0% |
| Cormorant Asset Management, LP | 5,000,000 | $15.6m | 0.8% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 4,418,674 | $13.7m | 0.0% |
| Woodline Partners LP | 4,200,142 | $13.1m | 0.0% |
| NORGES BANK | 4,112,401 | $12.8m | 0.0% |
| Opaleye Management Inc. | 3,863,800 | $12.0m | 1.1% |
| CITADEL ADVISORS LLC | 3,522,112 | $11.0m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 3,459,464 | $10.8m | 0.0% |
| FRANKLIN RESOURCES INC | 2,413,937 | $7.5m | 0.0% |
| GOLDMAN SACHS GROUP INC | 2,211,825 | $6.9m | 0.0% |
| MILLENNIUM MANAGEMENT LLC | 2,068,491 | $6.4m | 0.0% |
| CANTOR FITZGERALD, L. P. | 1,600,002 | $5.0m | 0.0% |
| MARSHALL WACE, LLP | 1,565,939 | $4.9m | 0.0% |
| RENAISSANCE TECHNOLOGIES LLC | 1,535,300 | $4.8m | 0.0% |
| UBS Group AG | 1,471,895 | $4.6m | 0.0% |
| Qube Research & Technologies Ltd | 1,426,840 | $4.4m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 1,418,108 | $4.4m | 0.0% |
| TWO SIGMA INVESTMENTS, LP | 1,410,931 | $4.4m | 0.0% |
| MORGAN STANLEY | 1,345,526 | $4.2m | 0.0% |