| FMR LLC | 30,923,878 | $551.1m | 0.0% |
| J. H. Whitney Equity Partners VI, LLC | 11,256,615 | $200.6m | 100.0% |
| COATUE MANAGEMENT LLC | 9,819,992 | $175.0m | 0.4% |
| BRAIDWELL LP | 8,256,032 | $147.1m | 5.4% |
| Sixth Street Partners Management Company, L.P. | 7,327,041 | $130.6m | 22.5% |
| PointState Capital LP | 6,828,835 | $121.7m | 1.6% |
| JPMORGAN CHASE & CO | 6,558,514 | $120.2m | 0.0% |
| BlackRock, Inc. | 5,536,798 | $98.7m | 0.0% |
| T. Rowe Price Investment Management, Inc. | 5,079,141 | $90.5m | 0.1% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 4,844,431 | $86.3m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 4,280,238 | $76.3m | 0.0% |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 3,958,531 | $70.5m | 0.3% |
| NEUBERGER BERMAN GROUP LLC | 3,590,963 | $64.0m | 0.0% |
| ORBIMED ADVISORS LLC | 2,806,811 | $50.0m | 0.9% |
| BNP PARIBAS FINANCIAL MARKETS | 2,370,268 | $42.2m | 0.0% |
| MILLENNIUM MANAGEMENT LLC | 2,202,647 | $39.3m | 0.0% |
| MAK CAPITAL ONE LLC | 1,937,229 | $34.5m | 4.8% |
| MORGAN STANLEY | 1,935,531 | $34.5m | 0.0% |
| Duquesne Family Office LLC | 1,894,450 | $33.8m | 0.6% |
| Clearbridge Investments, LLC | 1,595,877 | $28.4m | 0.0% |
| FIL Ltd | 1,548,918 | $27.6m | 0.0% |
| UBS Group AG | 1,423,371 | $25.4m | 0.0% |
| HRT FINANCIAL LP | 1,418,392 | $25.3m | 0.0% |
| CANADA PENSION PLAN INVESTMENT BOARD | 1,374,952 | $24.5m | 0.0% |
| STATE STREET CORP | 1,217,548 | $21.7m | 0.0% |