| BlackRock, Inc. | 4,145,061 | $99.8m | 0.0% |
| TANG CAPITAL MANAGEMENT LLC | 4,099,900 | $98.7m | 4.5% |
| MONTANOVA CAPITAL, LLC | 4,092,784 | $98.6m | 1.8% |
| STATE STREET CORP | 3,397,150 | $81.8m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 2,297,674 | $55.3m | 0.0% |
| GOLDMAN SACHS GROUP INC | 1,578,131 | $38.0m | 0.0% |
| RA CAPITAL MANAGEMENT, L.P. | 1,507,844 | $36.3m | 0.3% |
| Boxer Capital Management, LLC | 1,395,156 | $33.6m | 2.5% |
| GEODE CAPITAL MANAGEMENT, LLC | 1,372,286 | $33.0m | 0.0% |
| FMR LLC | 1,137,730 | $27.4m | 0.0% |
| CITADEL ADVISORS LLC | 814,444 | $19.6m | 0.0% |
| MERCER GLOBAL ADVISORS INC /ADV | 802,732 | $19.3m | 0.0% |
| Soleus Capital Management, L.P. | 761,737 | $18.3m | 0.6% |
| MORGAN STANLEY | 684,515 | $16.5m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 636,087 | $15.3m | 0.0% |
| UBS Group AG | 619,661 | $14.9m | 0.0% |
| DG Capital Management, LLC | 611,595 | $14.7m | 3.1% |
| Ikarian Capital, LLC | 604,215 | $14.5m | 1.6% |
| NORTHERN TRUST CORP | 503,532 | $12.1m | 0.0% |
| Balyasny Asset Management L.P. | 486,836 | $11.7m | 0.0% |
| J. Goldman & Co LP | 427,321 | $10.3m | 0.3% |
| Jones Hill Capital LP | 420,751 | $10.1m | 2.2% |
| VANGUARD FIDUCIARY TRUST CO | 372,539 | $9.0m | 0.0% |
| JPMORGAN CHASE & CO | 362,501 | $8.7m | 0.0% |
| GROUP ONE TRADING LLC | 272,609 | $6.6m | 0.0% |