| BAKER BROS. ADVISORS LP | 7,915,792 | $828.2m | 4.2% |
| Avoro Capital Advisors LLC | 3,400,000 | $355.7m | 3.2% |
| RTW INVESTMENTS, LP | 3,304,903 | $345.8m | 3.0% |
| PERCEPTIVE ADVISORS LLC | 3,197,200 | $334.5m | 5.0% |
| BlackRock, Inc. | 3,018,785 | $315.8m | 0.0% |
| STATE STREET CORP | 1,955,304 | $204.6m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 1,874,137 | $196.1m | 0.0% |
| NEA Management Company, LLC | 1,710,561 | $179.0m | 11.3% |
| Soleus Capital Management, L.P. | 1,704,318 | $178.3m | 6.1% |
| BANK OF AMERICA CORP /DE/ | 1,471,307 | $153.9m | 0.0% |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,451,014 | $151.8m | 1.6% |
| MORGAN STANLEY | 1,334,545 | $139.6m | 0.0% |
| TANG CAPITAL MANAGEMENT LLC | 1,314,594 | $137.5m | 6.2% |
| TORONTO DOMINION BANK | 1,258,758 | $131.7m | 0.2% |
| GEODE CAPITAL MANAGEMENT, LLC | 1,111,662 | $116.3m | 0.0% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,025,837 | $107.3m | 0.0% |
| WELLINGTON MANAGEMENT GROUP LLP | 906,595 | $94.8m | 0.0% |
| GOLDMAN SACHS GROUP INC | 870,449 | $91.1m | 0.0% |
| Point72 Asset Management, L.P. | 650,916 | $68.1m | 0.1% |
| Hood River Capital Management LLC | 628,411 | $65.7m | 0.5% |
| ALLIANCEBERNSTEIN L.P. | 530,922 | $60.6m | 0.0% |
| FMR LLC | 548,983 | $57.4m | 0.0% |
| Apis Capital Advisors, LLC | 538,000 | $56.3m | 5.5% |
| Holocene Advisors, LP | 533,147 | $55.8m | 0.1% |
| UBS Group AG | 520,946 | $54.5m | 0.0% |